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Synology DS1621+ Review: 2021’s Ultimate Home NAS Server, Delivered!

The Synology DS1621+ is a worthy upgrade to the DS1618+, which is still an excellent NAS server today. That’s to say, in many ways, the new server brings excellence to a new level.

No, it’s still not perfect. But if you’re looking to get the most out of a network-attached storage solution for a demanding home, or even a small business, the DS1621+ is an easy recommendation.

The server is worth every penny of its $800 price tag (diskless). And for this review, I went (almost) all out and invested a lot more than that. In the end, most of that proved to be money well spent.

Synology DSD1621 NAS 1
The Synology DSD1621+ NAS server in action.

Synology DiskStation DS1621+'s Rating

9 out of 10
Synology DS1621 NAS Server Front
Design and Setup


Powerful AMD CPU delivers fast and reliable performance

Robust DiskStation Operating System with tons of useful home and business applications, including Virtual Machines

Straightforward and consistent setup, upgrade, and management

Built-in M.2 NVMe slots

Lots of network storage options

Quiet operator


Expensive RAM upgrade

No built-in 10Gbps port (adapter required)

Only two camera licenses included

Synology DS1621+: The powerful AMD-based upgrade to the DS1618+

The DS1621+ is the immediate upgrade to the DS1618+ that came out in 2018. There was no 6-bay DiskStation Plus server in between the two.

(Per Synology’s naming convention, the DS1621+ is of the 2021 model year. However, it was first released in late 2020.)

Synology DS1621 vs DS1618 NAS Server Front
The Synology DS1621+ (left) looks virtually identical to the DS1618+ from the front.

And the two are very similar. In fact, Synology servers are generally conforming and consistent — a later model year is an incremental improvement of the previous one.

That said, the DS1621+ has everything the DS1618+ has plus some extras and differences, including:

  • Built-in NVMe M.2 slots for cache storage. Previously you must use a PCIe add-on adapter for the caching option with the DS1618+.
  • The new server now uses a more powerful AMD processor.
  • ECC RAM is now a requirement. ECC generally means more stable performance.

And here’s the most interesting part: The new servers come with a lower price tag at launch, which is $100 less than the DS1618+ at its time.

Familiar 6-bay design

Design-wise, the DS1621+ is almost identical to the previous model. It’s a 6-bay server with the ability to host two expansion units to house up to 16 internal drives. Out of the box, it can handle six. Considering you can get hard drives of significantly more than 10TB each, six drives are plenty in terms of storage.

Synology DS1621 NAS Server eSATA Ports
The back of the Synology DS1621+. Note the two eSATA ports and the PCIe add-on slot.

If you want to use standard 3.5-inch hard drives, the server is completely tool-free. You can install or remove each drive with bare hands. If you want to use 2.5-inch drives (HDDs or SSDs), though, you’ll need to screw them on their drive tray, and there are more than enough screws included in the box.

On the back, the server comes with the same amount of ports as did its predecessor, including four Gigabit LAN ports, two USB 3.0 ports, and two eSATA ports (to host expansion units).

Unfortunately, there’s no Multi-Gigi port, either. For that, you’ll need to resort to the server’s PCIe add-on slot. This slot can work with all Synology 10Gbps adapter cards, including the Dual-SFP+ E10G17-F2 and the Dual-BASET E10G18-T2. I tried both out for my testing, and they worked equally well.

The DS1621+ comes included with a 4GB random access memory (RAM) stick installed on one of its two memory slots on its underside.

Truth be told, the stock 4GB is enough for most cases — I used the DS1618+ for years with just that. However, upgrading the RAM is necessary if you intend to run lots of applications or multiple virtual machines.

Synology DS1621 NAS Server with E10G18 T2 installed
Here’s The Synology DS1621+ with the Dual 10Gbps BASET E10G18 T2 adapter installed.

Notes on the Synology DS1621+’s RAM upgrade

Per Synology, you can upgrade the server up to 32GB (2x 16B) of RAM. That’s likely because the company only sells 16GB and lower-capacity sticks. Since the server runs 64-bit Linux, I don’t see why it can handle more than 32GB.

In any case, keep the following in mind when it comes to memory upgrade:

  • It’s best to use RAM approved by Synology. (Which is very expensive, unfortunately.)
  • You can use certain third-party RAM if you want to take the risk. In this case, the server will give you an “unsupported” memory warning, which you can turn off in the Control Panel’s notification area.
  • It’s OK to use two sticks of different sizes (like a 4GB and an 8GB). Generally, in the server world, there’s no benefit in using two identical sticks. In my case, I tried the server out with 4GB and 16GB sticks.
  • The DS1621+ won’t work with the DS1618+’s stock RAM (it’s a non-ECC). So in an upgrade, you can’t move the old RAM over. However, the other way around is possible. The DS1618+ will take RAM used for the DS1621+, but only if you have removed its stock non-ECC stick.

Finally, the DS1621+’s two NVMe M.2 slots are hidden inside the server on its left inner wall. To get to them, you will need to remove a few drive trays from 1 to 4. Nonetheless, you can easily install or remove the SSD with bare hands.

Notes on using cache on Synology DS1621+

While the M.2 slots’ availability is a welcome change, their use only applies to applications that require fast random access performance. Examples of these applications include database access, video/audio editing, webpage serving, etc.

SSD caching is not necessary for sequential (file copy) performance. In fact, using a cache, in this case, might adversely affect the throughput speeds, as you’ll note in the performance section below.

Also, SSD caching should be used only with a hard-drive-based volume. If you use SSD as storage, caching is completely unnecessary.

Finally, the M.2 slots can only be used for caching. They will not work to host a regular data volume. (Hopefully, this will change in the future.)

Synology DS1621 NAS Server Seagate IronWolf 510 SSDs installed as cache
The Synology DS1621+ with two Seagate IronWolf 510 SSDs installed as cache

Hardware specifications: DS1621+ vs. DS1618+

Again, out of the box, like the case of the DS1618+, the new DS1621+ can handle up to six internal drives. If that’s not enough, you can add another ten via two DX517 expansion units.

CPUAMD Ryzen V1500B
 quad-core 2.2 GHz
Intel Atom C3538 
Quad-Core 2.1GHz
System Memory4GB ECC DDR4 4GB Non-ECC DDR4
Max Memory32 GB via two memory slots 
(16 GB x 2)
32 GB via two memory slots 
(16 GB x 2)
Dimensions6.53 x 11.1 x 9.57 in  
(166 x 282 x 243 mm)
6.53 x 11.1 x 9.57 in  
(166 x 282 x 243 mm)
Weight11.24 lbs (5.1 kg)11.24 lbs (5.1 kg)
Drive Bays66
Expansion SupportYes (two units)Yes (two units)
Drive InterfaceSATA 6Gbps/3Gbps; 
SATA 6Gbps/3Gbps; 
Maximum Raw Capacity96 TB (6x16TB Drives)96 TB (6x16TB Drives)
Bulit-in M.2 SlotsTwoNone
RAID TypesSHR, Basic, JBOD, RAID 0, RAID 1, 
SHR, Basic, JBOD, RAID 0, RAID 1, 
Ports / Interfaces4x RJ-45 1GbE LAN, 
3x USB 3.0, 2x eSATA
4x RJ-45 1GbE LAN, 
3x USB 3.0, 2x eSATA
PCIe Expansion1x Gen 3 x8 PCIe slot1x Gen 3 x8 PCIe slot
Add-in-card Support (not included)10GbE Network Interface Cards
(E10G18-T2 / T1, or E10G17-F2)
Dual SATA M.2 SSD adapter (cache); 
Or 10Gbe NIC Card
Operating SystemDSM 6.x (and later)DSM 6.x (and later)
File System (Internal / External)Btrfs, EXT4 / Btrfs, EXT4, EXT3, 
FAT, NTFS, HFS+, exFAT (via app)
Btrfs, EXT4 / Btrfs, EXT4, EXT3, 
FAT, NTFS, HFS+, exFAT (via app)
MSRP (Diskless)$799.99$899.99
Warranty3 years3 years
Sinology DS1621+ vs. DS1618+: Hardware specifications

The full hardware specifications of the DS1621+ can be found here.

An easy upgrade

For those thinking of migrating from the DS1618+ to the DS1621+, here’s some good news. It’s super easy.

Despite using completely different processors (AMD vs. Intel), you can migrate the two’s storage with ease. And the fact they use the same drive trays helps, too.

In my case, all I had to do is take the old server’s preoccupied trays and insert them into the new server in the same order.

After that, turn the new server on, run Synology Assistant from a connected computer, and follow the on-screen instruction to migrate. Shortly after, my new server was up and running with all the old data and settings.

You can also upgrade from most DiskStation servers to the DS1621+. Just make sure your old server has six or fewer internal drives.

The DS1621+ is the first Synology DiskStation that runs on an AMD Ryzen CPU.

Note on surveillance station in an upgrade

If you have bought extra camera licenses for the old server and want to use them with a new server, make sure you remove them from the old server before migrating the storage.

Like all Synology DiskStation servers, the DS1621+ includes just two camera licenses. That’s quite a shame considering it’ll make an excellent Surveillance system.

Synology DS1621+: Detail photos

Synology DS1621 NAS Server Front
The Synology DS1621+ comes with six drive bays.

To avoid accidental pullouts, the trays' latch has a lock and two keys are included with the server.
The DS1621+ shares the same drive trays and tray keys as those of the previous model.

Synology DS1621 NAS Server Fans
The new server has the same amount of ports as the DS1618+. It also has a PCIe add-on slot.

Synology DS1621 NAS Server Drive Bays
The Synology DS1621+ has an excellent drive bay design, allowing tool-free hardware installation.

Synology DS1621 NAS Server Front USB
Apart from the two USB 3.0 ports on the back, there’s also another one on the front.

Synology DS1621 NAS Server Left Side
It’s easy to remove the server’s top cover. The DS1621+ has its internal power supply on its right side.

Synology DS1621 NAS Server Right side
On the left side, there’s a PCIe add-on slot.

Synology DS1621 NAS Server 10Gbps Dual Ports
The Synology DS1621 with a dual-10Gbps PCIe network adapter card installed.

Synology DS1621 NAS Server M 2 Slots
The Synology DS1621+ comes with two M.2 NVMe slots for cache, located on the inside of its left wall.

Synology DS1621 NAS Server with Seagate IronWolf 510 SSD
I used two Seagate Ironwolf with the Synology DS1621+ for cache testing.

Synology DS1621 NAS Server SSD installed
You can easily install or remove an NVMe SSD on these slots without tools.

Synology DS1621 NAS Server WD RED SSD
For storage, I use two WD RED SA500 SSDs…

Seagate Ironwolf 10TB HDD
…and three Seagate Ironwolf hard drives.

Synology DS1621 NAS Server RAM Slot
The Synology DS1621+ comes with a 4GB RAM stick occupying one of the two memory slots on the underside.

Synology DSD1621 NAS 2
The Synology DS1621+ in action.

State of the art operating system and high-quality apps galore

Like the case of all other DiskStation servers, the DS1621+ runs DiskStation Manager (DSM) operating system, which is by far the best for NAS servers. The server comes with DSM 6.0 and will support DSM 7.0, which is currently available as a beta.

DSM 6 0 Apps
Like most Synology NAS servers, the DS1621+ has a package center with more than a hundred high-quality apps that add many functions to the server.

As a result, if you use a Synology server before, you’ll feel right at home with the DS1621+. The experience is conforming and persistent. For that reason, to avoid repeating myself, I detailed that in this separate frequently updated post on Synology servers.

See also  NAS Server Explained: Why It's Cool, and You'd Want a Synology, Too!

However, I want to add one thing about the DS1621+, which is the support for virtual machines.

While you can run VM Manager on all Plus servers, the DS1621+’s AMD Ryzen CPU makes VMs a much better experience. Specifically, my Windows 10 virtual machine now performed close to that of a regular computer.

Synology DS1621 Windows 10 VM
Windows 10 32-bit running as a virtual machine within the Synology DS1621+.

Synology DS1621+: Excellent performance

I tested the DS1621+’s data copy speeds using a 10Gbps connection via adapter cards, two 2TB WD RED SA500 SSDs (in SHR RAID, which is similar to RAID 1), and three 10GB Seagate Ironwolf NAS hard drives (in SHR RAID, which is similar to RAID5).

To make the result more meaningful and comparable, I retested the DS1618+ with the same storage volumes mentioned above and tested both servers without SSD caching and their 4GB stock RAM.

And the new DS1621+ server proved to be an excellent upgrade in copy performance alone, as you can see in the chart below.

Synology DS1621 NAS Performance

Additionally, just for kicks, I added two Seagate NAS SSDs as cache and attached them to the HDD-based volume. As expected, the copy speeds of this volume were now slightly slower.

Specially, via and 10Gbps connection, this volume deliver the sustained speeds of 348.37MB/s (read) / 330.36MB/s (write) and 350.60MB/s (read) / 353.79MB/s (write) with and without cache, respectively. Again, caching is really unnecessary when you need to transfer a lot of data.

But chances are you use the NAS server for a lot more than just raw file storage. In that case, and only then, it’s a good idea to invest in a couple of NVMe SSDs.

For this review, I used the DS1621+ for more than a month. During this time, it proved to be a much better solution with my extra upgrades, namely the SSD storage and additional 16GB of RAM. As stock configuration, though, it’d likely be very similar to the DS1618+.

That said, I’m now happy to use it as my main server. And considering how the DS1618+ has worked in the past almost three years — and it’s still working very well now –, I have no doubt the DS1621+ will last.


Again, the Synology DS1621+ is an excellent NAS server. The included six drive bays are a good number of those wanting to use multiple storage volumes. And the new powerful AMD CPU opens up a lot of potentials, especially in terms of virtualization.

(By the way, the DS1821+ is the same, plus two additional drive bays.)

That said, get one today and invest in some SSD storage and extra RAM, and you’ll have yourself the ultimate NAS server that delivers in all aspects of home networking and storage. And the effective implementation of virtual machines means small businesses won’t miss out either. I recommend it!

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12 thoughts on “Synology DS1621+ Review: 2021’s Ultimate Home NAS Server, Delivered!”

  1. I was looking at this model because of the 6 bays, this would be my first Synology NAS. My primary use for it would be as a Plex server with no transcoding and for backups for 2 PCs.

    Would I get much benefit from installing 2 nVMe SSDs? Reading your article I’m thinking maybe not. I’m also planning to use just the 4GB RAM but may upgrade in the future.

  2. I need to migrate/transfer data from my existing 1512+ to the 1621+ but the 1621+ but the former is ext4 and the latter is btrfs. I can’t seem to find any straightforward approach and I do NOT want to move the drives to the 1621+, I’m buying new drives for the new NAS. Any pointers?

    • There are many ways, Steve. First, connect both to a network, then:

      1. Use the Synology Migration Assistant app (package). This works well if you haven’t put any data on the new server. Or
      2. Transfer data directly from the old server to the new via Folder Sync or Synology Drive, Server (old hardware) -> Client (new hardware). Or
      3. Use normal data transferring using a computer.

  3. I’m curious as to why you went with the two storage SSDs and three HDDs, is there a benefit with app performance and VMs using the SSD storage over the hard drives?

    • Yes, Geno, I use the SSD volume for VMs and apps that require performance, the HDD volume is for basic storage — movies, backups, etc. There’s a huge performance difference between the two — part of which you can see on the copy charts in the review.

  4. Joe, If you don’t think you’ll ever buy more camera licenses, and you don’t plan on using the NVR features at all, then “only 2” licenses instead of four are not a ripoff. The unit is not sold as an NVR. Lack of 10G… well, that is a premium feature that very few will have infrastructure support for at home or in small businesses, so you’re off-base on the lack of that. Its inclusion is something that would just increase the base price of the unit. I agree on the ECC memory point though. This is a revenue item for Synology, who could just list verified/tested memory for those who want to buy alternatives. It’s the equivalent of the $59.99 HDMI cable you could buy from the store with the TV, or go to *mart and get a non-scary one for $6. You’re darn right I’m going to buy non-Synology RAM for my 1621+, and will put the savings towards another drive for the array.

    • Only 2 is a ripoff, so many people have more than 2 cameras, and Synology’s Surveillance Station competes with NVRs.

      Adding 10G would be minor expense, and huge future-proofing.

      You really made some weak arguments.

  5. Looks like yet another solid NAS from Synology. It should include 10G ethernet though. Synology RAM seems like a ripoff, and I’d likely trust non-recommended ECC. Only 2 camera licenses IS a ripoff — should be at least 4. I don’t think I’ll ever buy licenses, and have been instead using MotionEyes and direct camera interfaces; have been looking into BlueIris. All said, I still have a 13+ which still runs fine, and don’t really see a need to upgrade.


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